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이달의 kcj Hot Article / 2025년 1월 The Effects of Nicotine on Re-endothelialization, Inflammation, and Neoatherosclerosis After Drug-Eluting Stent Implantation in a Porcine Model
저자	Seok Oh, MD, PhD,^1,2,3 Ju Han Kim, MD, PhD,^1,2,3,4 Saleem Ahmad, PhD,^2,3 Yu Jeong Jin, BS^,2,3 Mi Hyang Na, BS,^2,3 Munki Kim, DVM, PhD,^2,3 Jeong Ha Kim, BS,^2,3 Dae Sung Park, PhD,^2,3 Dae Young Hyun, MD, PhD,^1,2,3 Kyung Hoon Cho, MD, PhD,^1,2,3,4 Min Chul Kim, MD, PhD,^1,2,3,4 Doo Sun Sim, MD, PhD,^1,2,3,4 Young Joon Hong, MD, PhD,^1,2,3,4 Seung-won Lee, MD, PhD,⁵ Youngkeun Ahn, MD, PhD, FACC, FSCAI,^1,2,3,4 and Myung Ho Jeong, MD, PhD, FACC, FAHA, FESC, FSCAI, FAPSIC^1,2,3,4,6
소속	¹Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea. ²The Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by the Korean Ministry of Health and Welfare, Gwangju, Korea. ³The Korea Cardiovascular Stent Research Institute, Chonnam National University, Gwangju, Korea. ⁴Department of Cardiology, Chonnam National University Medical School, Gwangju, Korea. ⁵Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea. ⁶Department of Cardiology, Gwangju Veterans Hospital, Gwangju, Korea.
Background and Objectives Cigarette smoking is a major risk factor for atherosclerosis. Nicotine, a crucial constituent of tobacco, contributes to atherosclerosis development and progression. However, evidence of the association between nicotine and neointima formation is limited. We aimed to evaluate whether nicotine enhances neointimal hyperplasia in the native epicardial coronary arteries of pigs after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Methods After coronary angiography (CAG) and quantitative coronary angiography (QCA), we implanted 20 DES into 20 pigs allocated to 2 groups: no-nicotine (n=10) and nicotine (n=10) groups. Post-PCI CAG and QCA were performed immediately. Follow-up CAG, QCA, optical coherence tomography (OCT), and histopathological analyses were performed 2 months post-PCI. Results Despite intergroup similarities in the baseline QCA findings, OCT analysis showed that the nicotine group had a smaller mean stent and lumen areas, a larger mean neointimal area, greater percent area stenosis, and higher peri-strut fibrin and inflammation scores than the no-nicotine group. In immunofluorescence analysis, the nicotine group displayed higher expression of CD68 and α-smooth muscle actin but lower CD31 expression than the no-nicotine group. Conclusions Nicotine inhibited re-endothelialization and promoted inflammation and NIH after PCI with DES in a porcine model.
첨부파일1	kcj-55-50-abf001.jpg (다운 10회)

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