정혜문, 윤지현, 최의영, 김종윤, 민필기, 이병권, 윤영원, 홍범기, 임세중, 권혁문 |
BACKGROUND: It is well known that glycoalbumin is independent risk factor of atherosclerosis in patients with Diabetes mellitus(DM). The aim of this study was to investigate the value of glycoalbumin for predicting multivessel coronary artery disease(CAD).
METHODS: The study population included 326 patients (210 men, age 64±11 years) who underwent coronary angiography for suspected CAD. We devided patients into three groups based on absence (normal, n=71) or presence (1 vessel disease, n=69 and multivessel disease, n=186) of documented CAD at coronary angiography. CAD was defined as > 50% luminal narrowing of at least one major epicardial coronary artery.
RESULTS: Multivessel group was older (66±10 vs. 61±10, p<0.001) and had more male patients (76% vs.41%, p<0.001). Fasting blood glucose (FBG) (117±41 vs. 105±26, p=0.038), HbA1c (6.8±1.4 vs. 6.1±1.0, p<0.001), glycoalbumin (18.6±17.5 vs. 13.4±3.1, p=0.012) and MS score (2.7±1.2 vs. 2.3±1.2, p=0.005) were higher in multivessel group than normal group. HDL (37±10 vs. 45±16, p<0.001) and eGFR (77±23 vs. 91±30, p<0.001) were lower in multivessel group.
In multivariate logistic regression analysis detecting independent predictors of multivessel CAD, older age and higher glycoalbumin were significant predictor of multivessel CAD.
CONCLUSIONS: Increased glycoalbumin is associated with multivessel CAD, and may useful for pedicting multivessel CAD like other major risk factors.
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