Background竊�There have been limited data whether the presence of low left ventricular ejection fraction (LVEF < 40%) at baseline can adversely impact on the long term clinical outcomes in non-myocardial infarction (non-MI) patients (pts) undergoing elective percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Method: The study population consisted of consecutive 1119 non-MI pts underwent PCI with DESs from January 2004 to April 2010. We compared the cumulative major clinical outcomes of non-MI pts with Low LVEF group (< 40 %, n= 91 pts, 31.5짹8.27 %) with those of Preserved EF group (��� 40%, n=833 pts, 56.8짹6.8 %) up to 12 months. Results: The baseline characteristics were balanced between Low EF group and Preserved EF group except pts with low LVEF group had more smoking history (p<0.001) than pts with preserved LVEF group. At 12 months, the incidence of cardiac death, repeat PCI, target vessel revascularization (TVR)-major adverse cardiac events (MACE) and total MACE were higher in the Low LVEF group (Table). Multivariate analysis showed that low LVEF was an independent predictor of total MACE at 12 months (Adjusted OR: 1.980, 95% CI:1.145-3.422, p=0.014). Conclusion: In our study, Low LV EF at baseline was associated with high incidence of major adverse clinical outcomes up to 12 months. Low LVEF in non-MI pts was an independent predictor of total MACE in pts undergoing elective PCI with DES in real world clinical practice.