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ȣ - 550071 81 |
관상동맥스텐트시술환자에서 sarpogrelate를 추가한 삼자요법의 혈소판억제효과 : 이자요법과의 무작위 교차 비교 연구 |
동아대학교병원 순환기내과¹, 임상시험센터², 하얼빈의과대학 제4병원 심장내과³ |
조용락¹ , 김무현¹ ², 장홍철², 어룡호³, 백희경¹, 박경일¹, 박종성¹, 박태호¹, 김영대¹ |
Background and Objectives: Sarpogrelate HCL (Anplag) is a 5-hydroxytryptamine subtype 2A (5-HT2A) receptor antagonist. A previous study reported that adjunctive anplag of 300 mg to aspirin and ticlopidine reduced the rate of in-stent restenosis compared to control group. We sought to assess effects of 300-mg anplag in addition to aspirin and clopidogrel on platelet inhibition in patients underwent drug-eluting stents insertion. Subjects and Methods: This is a randomized, cross-over designed, prospective study. Forty-four eligible patients were enrolled and received dual or triple antiplatelet therapies for 2 weeks and then crossed-over and administered to opposite therapy for 2 weeks. Platelet function tests by multiple electrode aggregometry and light transmittance aggregometry were performed just before and 2 and 4 weeks after administration. Results: Baseline platelet function was measured at 24±2 hours after administration of loading doses of 300-mg aspirin and 300-mg or 600 mg clopidogrel. There was no significant difference in comparison of platelet inhibition in both groups (table). Conclusions: Our data suggested an adjunctive sarpogrelate HCL of 300 mg to aspirin and clopidogrel did not show an additional benefits on laboratory platelet inhibition compared to conventional dual therapy.
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Table. Difference between Dual and triple therapy
Platelet Fuction tests |
Dual |
Triple |
p-value |
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(n=43) |
(n=41) |
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LTA(Chrono-Log,Havertown,PA,USA) |
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MPA(10-mM ADP-induced) |
49.0±14.6 |
45.5±15.3 |
0.292 |
MPA(0.5-mM AA-induced) |
3.0 ± 0.2 |
2.5 ± 0.2 |
0.125 |
MPA(2 mg/ml collagen-induced) |
19.1±12.5 |
17.4±15.6 |
0.593 |
MEA(Dynabyte,Munich,Germany) |
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|
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ADPtest(U) |
46.5±21.9 |
46.2±16.7 |
0.949 |
ASPtest(U) |
17.8±12.8 |
16.6±8.6 |
0.623 |
COLtest(U) |
44.7±18.2 |
43.0±15.9 |
0.647 | values are mean±SD, Results from independent t-test
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