이재범, 황희정, 정우백, 최윤석, 장기육, 허성호, 이만영, 정욱성, 승기배 |
Background
The level of the N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is known to be a strong predictor of mortality among patients with acute coronary syndromes. However, it remains elusive whether it can be a prognostic marker in patients with chronic stable coronary artery disease. We investigated the association of preprocedural NT-pro-BNP level and clinical outcomes in stable angina patients with normal left ventricle(LV) systolic function after percutaneous coronary intervention(PCI)
Methods
A total of 1,285 patients (mean age = 64.15 ± 9.89 yrs; male = 755 (58.8%) who underwent PCI with stable angina was analyzed retrospectively in catholic registry study. We excluded the patients with LV ejection fraction less than 50 % or renal dysfunction (serum creatinine >2.0 mg/dL). NT-pro-BNP was measured on admission prior to PCI. We compared MACE incidence between 4 groups divided by the 25% percentile level of NT-pro-BNP.
Results
Among baseline characteristics, the patients with highest quartile of NT-pro BNP level were older, more prevalent of female gender, hypertension and multivessel disease. They also had higher BMI, serum creatinine, fasting glucose level and hs-CRP but lower hemoglobin compared with the patients with lowest quartile of NT-pro BNP.
On multivariate analysis, the patients with highest quartile of NT-pro BNP was not significantly associated with increased risk of MACE (death from any casue, MI, stroke, TLR and TVR) compared with those with lowest quartile (p=0.458, adjusted odds ratio, 0.837(95% CI, 0.523-1.339)).
Conclusions
Differing from acute coronary syndrome, preprocedural NT-pro-BNP levels does not show the role as a predictor of clinical outcomes after PCI in stable angina with preserved LV systolic function.
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