Backgrounds: Many reports have suggested that DES is effective for ISR of bare metal stent. Even though several reports have suggested that an alternative type of DES would be better theoretically, however little is known regarding clinical outcome with repeated DES treatment for ISR of DES. The purpose of the present study is to compare the efficacy of treatment utilizing the homo- versus hetero-type DES for ISR of DES. Methods: From May 2004 to January 2009, we analyzed consecutive 55 patients with 62 lesions previously treated with DES who presented with angiographic ISR, and were treated with repeat homo-DES (18 patients with 21 lesions) or hetero-DES (37 patients with 41 lesions). Clinical follow-up commenced from the point at which the DES-ISR was detected. Clinical follow-up was obtatined in 100% of patients. The mean clinical follow-up period was 24짹20.8 months. Result: There was no difference in patient, lesion, procedure characteristics. 7.3% (n=4) of DES-ISR were associated with stent fracture. The incidence of in-hospital stent thrombosis (acute or subacute) was greater in the homo-DES treatment group [11.1% (n=2) vs. 0% (p=0.039)]. During the follow-up period, no significant difference was seen between two group regarding MACE rate (defined as death, MI, and TLR). including of no mortality, 5.6% (n=1) vs 0% in MI, and 11.1% (n=2) vs 2.7% (n=1) in TLR. Most of MACE (n=3) at follow-up were associated with pre-existing stent fracture. Conclusion: Re-implantation of DES (homo-or hetero-type) for the treatment of DES-ISR is acceptable. However, the homo-DES treatment for DES-ISR seems to be associated with acute event such as acute or subacute stent thrombosis, probably due to hypersensitivity reaction to same polymer. The chronic mechanical insult by stent fracture may be associated TLR after repeated DES treatment for ISR of DES. Further studies are required to determine the optimal treatment for DES-ISR.