Purpose: Microalbuminuria is known to predict the cardiovascular morbidity and mortality and recognized as a marker of vascular dysfunction. However, the mechanism between microalbuminuria and atherosclerotic vascular disease is not fully known. Pulse wave velocity (PWV) is another measure of atherosclerosis, it reflects arterial stiffness. In our study, we evaluated the association between micoralbuminuria and arterial stiffness presenting as brachial-ankle PWV (baPWV). Methods: 677 patients were included in this study. Microalbuninuria was defined as a urine albumin:creatine ratio (ACR) of ≥30mg/g Creatinine but < 300mg/g Creatinine. The patients were classified into 2 groups : normoalbuminria (n=511) and micoralbuminuria (n=166). For every patients, the average of left and right baPWV was calculated for the analysis. Results: The patients with microalbuminuria were older and had more frequent hypertension, elevated high-sensitive C-reactive protein (HsCRP) and systolic blood pressure. The patients with microalbuminuria had significantly higher baPWV (1737.29±432.93mm vs. 1562.14±305.31mm, p<0.001). Carotid mean IMT and presence of carotid plaque was not significantly different between 2 groups. In multivariate analysis after significant traditional cardiovascular risk factors, baPWV was significantly associated with microalbuminuria (OR 1.001, p=0.005). 1562. On multivariate linear regression analysis after adjustment significant traditional cardiovascular risk factors, baPWV was significantly associated with urinary ACR (OR 0.161, p=0.001). Conclusions: Our data suggest that micoralbuminuria might be significantly associated with arterial stiffness presenting as baPWV
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