Background : Diastolic dysfunction and the clinical syndrome of diastolic heart failure (HF) have become well recognized largely due to increased recognition of diastolic mechanism as a cause for heart failure. But, the prognostic factors for diastolic heart failure were not still defined. Methods and Results : The Korean Heart Failure registry (KorHFR) prospectively studied the characteristic and outcomes in a broadly sampled patients hospitalized with worsening HF and the outcomes were followed by 50 university centers in South Korea. Of the total cohort of HF 3,200 patients, 678 patients (21.2%) with heart failure associated preserved left ventricular (LV) systolic function were analyzed. During follow up, all-cause mortality was 17.1%. (114 patients) We analyzed clinical characteristics and outcomes of diastolic heart failure patients. Univariate analysis revealed that predictors for survival were age > 65, anemia [female hemoglobin (Hb) <12.0g/dL, male Hb < 13.0g/dL by WHO definition], Systolic blood pressure < 100 mmHg, pH on initial arterial blood gas analysis < 7.2, Sodium <130 mEq/L, and NT-proBNP > 400 pg/ml. On multivariate analysis, age (HR 1.747, 95% CI 1.079-2.830, p=0.023), anemia (HR 1.909, 95% CI 1.226-2.973, p=0.004), systolic blood pressure (HR 1.792, 95% CI 1.229-2.613, p=0.002) remained as independent predictors.
Conclusions: In patients with HF associated preserved LV systolic function, age, anemia and systolic blood pressure were helpful to predict the prognosis in KorHFR.
Key Words: Diastolic heart failure; Prognosis; Anemia; Systolic blood pressure
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