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ȣ - 540571 9 |
Randomized Comparison of a Double Anti-Platelet Therapy and Triple Anti-Platelet Therapy on Platelet Aggregation in Type 2 Diabetic Patients Undergoing Drug Eluting Stent Implantation |
인제의대 부산백병원¹ , 인제의대 해운대백병원² |
양태현¹, 조영완¹ ,진한영¹ ,박상율¹ ,박진한¹ ,서영경¹ ,서정숙¹ ,김동기² ,김웅² ,설상훈² ,장재식¹ ,김대경¹ ,김두일² ,김동수¹ |
Background: Platelet reactivity is enhanced in diabetic patients compared with non-diabetic patients. Several studies demonstrated that triple anti-platelet therapy could produce more potent inhibition of platelet aggregation. Whether this enhanced effect can be maintained in diabetic patients is not well known.
Methods: Sixty type 2 diabetic patients were prospectively randomized to double (aspirin, clopidogrel) or triple (aspirin, clopidogrel, cilostazol) anti-platelet therapy after drug eluting stent (DES) implantation. Platelet function parameters included adenosine diphosphate (ADP) 20 and 5 μmol/L induced maximal platelet aggregation (MPA) and late platelet aggregation (LPA) at pre-discharge and 30 days after randomization using light transmittance aggregometry.
Results: ADP 20 μmol/L induced MPA at 30 days was significantly reduced in the triple group compared with the double group (p=0.044; primary end point) (Figure). All other platelet aggregation parameter at 30 days was significantly reduced in the triple group compared with the double group. Pre-discharge aggregation parameter tended to be lower in the triple group compared with the double group.
Conclusion: Triple anti-platelet therapy resulted in enhanced anti-platelet effects compared with double anti-platelet therapy in type 2 diabetic patients undergoing DES implantation.
Keyword: Diabetes, Antiplatelet drugs, Platelet aggregation
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