Background: We hypothesize that left ventricular (LV) relaxation of dialysis patients is more severely depressed than non-dialysis patients with diastolic dysfunction. The aim of present study was to evaluate the diastolic parameters in dialysis patients with elevated LV filling pressure, compared with non-dialysis patients.
Methods: We studied 24 dialysis and 24 non-dialysis patients with elevated LV filling pressure. Retrospective echocardiographic study including tissue Doppler imaging (Ea) was obtained in all patients of elevated LV filling pressure with normal LV ejection fraction.
Results: The mean LV mass index and left atrial volume index were no significantly different in dialysis and non-dialysis patients (129 ± 24 vs. 123 ± 23 g/m², and 44 ± 11 vs. 45 ± 12 mL/m², respectively). The mean E/Ea representing LV filling pressure was almost same in both groups (13.8 ± 3.4 vs. 13.6 ± 3.0 cm/s), However, the mean mitral E of dialysis patients was significantly lower and mitral A was significantly higher than non-dialysis patients (80 ± 18 vs. 92 ± 20 cm/s, p=0.04, 109 ± 20 vs. 88 ± 23 cm/s, p<0.001, respectively). The mean lateral Ea of dialysis patients was significantly lower than non-dialysis patients (5.9 ± 1.1 vs. 6.9 ± 1.5 cm/s, p=0.01).
Conclusions: Although LV filling pressure was similar in dialysis and non-dialysis patients, each parameter (E, Ea) of LV filling pressure were significantly different. Our study suggests that the high LV filling pressure in patients with dialysis might be mainly caused by severely depressed LV relaxation.
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