Objective We investigated procedural and clinical outcome of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in single institution. Methods From December 2006 to December 2009, PCI were performed in 165 patients (111 male, 67.3%, mean age 60.5짹11.7 years) with 169 CTO lesions. Medical records and radiographic information were reviewed to determine the procedural technique, the peri-procedural complications and the clinical outcomes. Results The target artery included the left anterior descending artery (76 lesions, 45.0%), the right coronary artery (62 lesions, 36.7%), and the left circumflex artery (31 lesions, 18.3%). The success rate of primary attempt was 80.4% (123 lesions) and overall success rate was 81.1% (137 lesions). The balloon angioplasty was achieved in 26 lesions (19.0%) and stent was deployed in 111 lesions (drug eluting stent : 99 lesions, bare metal stent : 12 lesions). The mean number of stents per lesion was 1.1짹0.7. Retrograde approach was used for 1 lesion. In 30 lesions, the guide wire could not pass the lesion (93.8%) and in 2 lesions, the balloon catheter could not pass the lesion (6.3%). The mean procedure time was 68.0짹32.2 minutes and the mean amount of dye was 319.9짹115.5 ml. Contrast induced nephropathy was noted 5 patient (3%). Acute vessel occlusion due to stent thrombosis was noted in 1 patient during PCI. Otherwise, no urgent coronary artery bypass graft or PCI were necessary. During follow-up period (mean 19.9짹10.8 months), the major adverse cardiac event (MACE) occurred in 10 patients (7.3%, 2 cardiac death, 2 non-fatal MI, 9 TLR). Restenosis was noted 8 lesions (19%) of patients performed follow-up angiography (42 patients, 30.7% of all patients). The cumulative MACE free survival rates at 30 day, 1 and 2 years were 99.0, 96.8 and 89.6%, respectively. Conclusions Our data showed that PCI for chronic total coronary occlusion is safe and effective, with a few complications.