Background: The safety and clinical outcomes of percutenous coronary interventions (PCI) in octogenarians (���80 years) in western population is available in the literature. But the data about the individual components of angiographic and major clinical outcomes were lacking in the current drug-eluting stent (DES) era especially in the Asian population. Method: The study population consisted of 1969 consecutive patients (pts) who underwent PCI with DESs from April 2006 to September 2009. Angiographic and clinical outcomes up to 6 months of octogenarians (n=180 pts, 9.15%) were compared with non-octogenarians (n=1789 pts.90.85%). Results: Baseline characteristics were similar between the two groups except the Octogenarians had more females (55.6% vs. 31.7 %), hypertensives (72.8% vs. 62.7%), cerebrovascular events (8.9% vs. 5.6%), chronic renal insufficiency (21.1% vs. 9.4%), more likely to present with acute myocardial infarction (AMI) and cardiogenic shock and less likely to receive antiplatelet therapy at the time of discharge. Half of the study population underwent 6-8 month routine angiographic follow up. At 6 months, although the Octogenarians showed similar angiographic outcomes in the multivariate analysis but the overall target vessel revascularization-major adverse cardiac events (TVR-MACE) were higher as compared with non-octogenarians (Table). Conclusion: Octogenarians had worse baseline clinical characteristics and showed higher mid-term TVR-MACE as compared to the non-octogenarians and special care should be emphasized in this particular subset of pts even in the DES era.