| 박예민¹, 신미승¹, 최동주² , 전은석² , 조명찬² , 채성철² , 유규형² , 오병희² , 이명묵² |
Background: The obesity has been known to be associated with diastolic dysfunction of the left ventricle (LV). Previous studies suggested that obesity has been linked to a wide spectrum of cardiovascular abnormalities including diastolic heart failure. This study was to evaluate the influence of obesity on the left ventricular diastolic function in patients with heart failure with preserved ejection fraction (HFPEF).
Methods: We interrogated the KorHF Registry database composed of 3,200 patients, which enrolled hospitalized patients with acute decompensated HF. Among them, 743 patients (26.1%) had HFPEF and 635 patients with available data could be analyzed. Obesity was defined as BMI ≥ 25kg/m2. Patients were divided into two groups according to obesity by body mass index (BMI). Group I (n= 426, 67.1%) represented normal BMI (<25kg/m2) while group II (n=209, 32.9%) represented BMI≥25kg/m2.
Results: Mean age was higher in group I (70.9±13.0 years vs. 67.6±13.5 years, p=0.003), and proportion of female was similar in both groups (62.2% vs. 63.6%, p=0.73). LV end-systolic volume index (25.3±16.6 vs. 24.6±12.3 ml/m2, p=0.77), LV end-diastolic volume index (56.5±28.4 vs. 53.7±21.3 ml/m2, p=0.48), left atrium volume index (42.4±39.6 vs. 39.1±19.3 ml/m2, p=0.54), LV ejection fraction (56.2±8.9 vs. 55.4±7.4%, p=0.55), E velocity (0.92±0.55 vs. 0.83±0.36 m/sec, p=0.08), E/A ratio (1.38±2.66 vs. 1.17±0.90, p=0.40), deceleration time(207±71 vs. 214±73 m/sec, p=0.34), E/E’ (17.5±11.2 vs. 16.7±8.4, p=0.47) and right ventricular systolic pressure (33.9±15.9 vs. 33.3±15.9 mmHg, p=0.76) were not significantly different between two groups. A velocity was lower in group II (0.87±0.47 vs. 0.78±0.28, p=0.045).
Conclusion: Age can influence the diastolic function. However, systolic and diastolic functions were not significantly different except A velocity between two groups despite younger age of obesity group. These results can be explained by the influence of diastolic dysfunction caused by obesity itself in patients with HFPEF.
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