Background: Heparinization of surfaces has been shown to be a successful strategy to prevent thrombus formation and various approaches of surface heparinization have been reported. Inspired by the composition of adhesive proteins in mussels, we used dopamine to form thin, surface-adherent films onto a stent surface. Dopamine perform well binding agents for coating inorganic surfaces, including the stent materials. Moreover, it have been reported that improvement of hydrophilicity and substantial reduction in protein adsorption by dopamine. Objective: We hypothesizes that these properties of the dopamine may contribute to improve cell adhesion and prevent platelet adhesion onto stent surface. The aim of this study was to assess the biocompatible effect of dopamine-mediated heparin (HPM) coating of a stent graft. Methods: HPM was synthesized by bonding chemically between dopamine and heparin. Stainless steel (316L) was immerged in HPM solution for 24 h. For hemocompatiblity examination, platelet rich plasma (PRP) was prepared from fresh porcine blood, and was treated to the surface. After 180 min of incubation, the morphologies and distribution of platelets for the surface was assessed by calculating the number and the comparing size of platelets, and morphologies of platelet on the surface were imaged by scanning electron microscope. Cytotoxicity of HPM coating was evaluated by XTT assay for 7 days. Adherent cells on the surface were observed by optical microscope after 24 h incubation. Non-coated 316L was employed as a control. Results: Hemocompatibility evaluation reveals the number of platelet on the HPM coated surface (n=6) was clearly less than that on the control group (n=6) in the same condition. Moreover, a remarkable difference can be seen in shape of adhesive platelets. The platelets on the HPM coated groups were observed with few agglomerations and distortions, but the platelets on the non-coated specimen was observed swarms form which is also morphological index for activated platelet form. The present HPM coating did not show any cytotoxicity in vitro according to the XTT bioassay experiment, and eventually any influence on cell proliferation and morphology. Conclusion: These results suggest that HPM coating have potential application for coating stent surface.