Objectives Although edge stenosis (ES) is a main limitation of drug-eluting stent, the predictive factors for ES were not well known. So we evaluated the relationship between clinical/ procedural factors, chronic arterial responses and ES after PCI with paclitaxel-eluting stent (PES). Methods Eighty-eight angina patients (52 men; 62.2짹8.3 years of age) were divided into group I (n=13, ES) or group II (n=75, no ES) according to ES. Intravascular ultrasound of lesion, intra-stent and 5-mm long segments immediately proximal and distal to the stent was performed to determine arterial remodeling, volume and area of Vessel, Plaque, Lumen before and after the procedure, at the 9-month follow-up. Results Baseline characteristics were not different between two groups except diabetes (group I : 61.5%, II : 22.7%, P=.007). Positive remodeling of lesion was more common in group I than II (76.9 vs. 38.7 %, P=.015). Baseline reference Vessel area tended to be smaller in group I than II (proximal, 11.8짹3.6 vs. 14.4짹4.6 mm², P=.055; distal, 8.9짹4.0 vs. 11.4짹4.3 mm², P=.060). In proximal 1mm and distal 1mm reference segments, proximal Lumen area (7.3짹1.8 vs. 8.2짹2.0 mm², P=.091) and distal Vessel area (6.5짹2.3 vs. 7.7짹2.4 mm², P=.066) also tended to be smaller in group I than II. Moreover, distal Lumen area was significantly smaller in group I than II (6.2짹1.7 vs. 7.6짹1.9 mm², P=.012). In multivariate logistic regression analysis, diabetes (OR : 4.8, 95% confidence interval (CI) 1.13-17.52, P=.016), positive remodeling (OR : 4.7, 95% CI 1.14-19.25, P=.033) and distal lumen area after PCI (OR :0.4, 95% CI 0.12-1.00, P=.049) were significant predictors for ES after PES implantation (table). Conclusions The ES after PES implantation was associated with diabetes, positive remodeling of the lesion and smaller luminal area of distal 1 mm stent after PCI.