Background: Transient left ventricular apical ballooning is characterized by chest pain, electrocardiographic changes and LV apical akinesia mimicking anterior myocardial infarction in the absence of coronary artery disease. This study aimed to assess the serial electrocardiographic changes between stress cardiomyopathy and non-reperfused anterior myocardial infarction. Patients and Methods: Ten patients(75짹12 years, Male 3) with stress cardiomyopathy and five patients(84짹12 years, Male 3) with anterior myocardial infarction without reperfusion therapy were compared the electrocardiogram serially. Results: An abnormal Q wave at presentation was more frequent in AMI and persisted and progressed in almost AMI patients whereas the Q wave is appeared in inferior lead at presentation and disappeared in stress cardiomyopathic patients during follow-up. The QTc interval was significantly longer in stress cardiomyopathy than AMI (521짹57 vs 453짹38 ms, p<0.05). During follow-up, the giant T-wave inversion (> 1mV) displayed and commonly persisted 1-3 weeks after intial presentation in stress cardiomyopathic patients. Conclusion: ECG findings in patient with stress cardiomyopathy are significantly different from those in AMI patients. During follow-up, no Q wave, a longer QTc interval and a giant T-wave inversion in precordial leads are typical findings and these findings commonly persisted the 1-3 weeks in stress cardidomyopathic patients.