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ȣ - 530721 16 |
The role of mid-term follow up high sensitivity C-reactive protein on long term outcomes in patients who underwent percutaneous coronary intervention |
계명대학교 동산의료원 심장내과 |
신홍원, 손지현, 한춘덕, 조윤경, 박형섭, 윤혁준, 김형섭, 남창욱, 허승호, 김윤년, 김권배 |
Backgrounds : High level of high sensitivity C-reactive protein(hsCRP) is known to be associated with increased coronary events and poor prognosis in acute myocardial infarction. We studied whether mid-term follow-up hsCRP (f/u hsCRP) after percutaneous coronary intervention(PCI) is associated coronary events and prognosis or not.
Methods : In this single-center retrospective cohort study, 763 patients, who underwent PCI, were estimated f/u hsCRP after 4 month. We compared group A (f/u hsCRP ≤ 0.5, N=677) with group B (f/u CRP> 0.5, N=86). Major adverse cardiac events(MACE) were associated at 2 years after the procedure. The cutoff point of hsCRP was normal range of our hospital.
Results : Group B had more elderly patients (61.4±10.2 vs. 65.5±10.1, p=0.001), higher serum creatinine (1.2±1.1 vs. 1.5±1.4, p=0.044), lower body mass index (24.6±3.0 vs. 23.8±3.2, p=0.027) and lower ejection fraction (55.8±11.8 vs. 52.3±13.7, p=0.026). One year MACE, all cause of death, myocardial infarction and 2 year MACE, all cause of death were higher in group B. Multivariate analysis disclosed that f/u hsCRP and serum creatinine were a significant independent predictor of 1 year MACE and 2 years MACE.
Conclusions : Therefore elevated mid-term f/u hsCRP level in patients who underwent PCI seems to be a good valuable factor for the long term outcomes.
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f/u hsCRP≤0.5 |
f/u hsCRP>0.5 |
P value |
Mean value of
f/u hsCRP, mg/dl |
0.2±0.1 |
1.4±1.0 |
<0.001 |
Age |
61.4±10.2 |
65.5±10.1 |
0.001 |
Ejection fraction, % |
54.2±12.0 |
59.0±11.2 |
0.086 |
Body mass index, kg/m2 |
24.6±3.0 |
23.8±3.2 |
0.027 |
Creatitine, mg/dl |
1.2±1.1 |
1.5±1.4 |
0.044 |
One year MI, % |
0.4 |
2.4 |
0.038 |
One year MACE, % |
4.9 |
13.4 |
0.002 |
One year death, %
Two years MI, %
Two years MACE, % |
1.3
1.1
6.9 |
7.2
3.3
18.0 |
<0.001
0.149
0.003 |
Two years death, % |
1.9 |
8.2 |
0.004 |
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