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ȣ - 530704 149 |
Vascular response to overlapping drug-eluting stents: SES vs. PES |
계명대학교 동산병원 |
조윤경, 허승호, 김미경, 김보람, 한춘덕, 박형섭, 윤혁준, 김형섭, 남창욱, 김윤년, 김권배 |
Background: Increased drug dose in the overlap segment might be associated with vascular responses. The aim of this study is to investigate the vascular response using IVUS between SES and PES.Methods: A total of 18 patients with overlapping stents (12 SES and 6 PES) were imaged with serial IVUS after procedure and at 9 months. Volumetric IVUS analysis was performed. Vascular responses were assessed at single stent strut (non-OL) regions and the overlap (OL) region.Results: In PES, the changes of mean vascular volume (VVI) and mean peri-stent plaque volume (PVI) were not different. The change of VVI in SES also showed no difference. Although the difference did not reach statistical significance, the change of PVI in SES tended to be less at non-OL regions. There were no significant difference in the frequency of late-acquired ISA with SES and PES in either non-OL regions or OL region.Conclusion: Exaggerated vascular responses were not present at OL region compared with non-OL regions in both SES and PES groups.
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Comparison of vessel responses between SES and PES |
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SES |
PES |
delta VVI |
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OL |
1.28±1.84 |
1.66±2.12 |
non-OL |
0.72±0.95 |
1.26±2.66 |
delta PVI |
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OL |
1.42±1.69 |
1.23±1.63 |
non-OL |
0.82±1.04 |
0.62±1.66 |
NIVI |
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OL |
0.11±0.18 |
0.44±0.37 |
non-OL |
0.10±0.20 |
0.94±0.50* |
Comparison of vessel responses among 2 regions |
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OL |
non-OL |
SES |
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NIVI |
0.11±0.18 |
0.10±0.20 |
delta VVI |
1.28±1.84 |
0.72±0.95 |
delta PVI |
1.42±1.69 |
0.82±1.04 |
PES |
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NIVI |
0.44±0.37 |
0.94±0.50 |
delta VVI |
1.66±2.12 |
1.26±2.66 |
delta PVI |
1.23±1.63 |
0.62±1.66 |
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