Background: Unprotected left main (LM) bifurcation angioplasty with drug-eluting stent (DES) is being performed either by simultaneous or sequential kissing stenting but their safety and efficacy was not reported yet. We evaluated the safety and efficacy of different kissing stenting strategy in true LM bifurcation intervention up to 12 months.Methods: All patients (pts) with unprotected LM bifurcation lesion electively treated with sirolimus-(SES; Cypher), paclitaxel (PES; Taxus) or zotarolimus (ZES; Endeavor)-eluting stent by kissing stenting strategy were enrolled. LM bifurcation lesions were treated by kissing stenting, crushing technique or stent crossover (Stent/Balloon) and this study is to assess whether the two different kissing stenting strategies either by Simulataneous Kissing or Sequential Kissing would have smilar clinical and angiographic outcomes up to 12 months. Results: Out of total 117 pts (Male 73, mean age, 64.1 짹 9.9 years) who underwent standard percutaneous coronary intervention (PCI) with DES in unprotected LM lesion, a total 28 pts who had LM bifurcation lesion (28/117, 23.9%) were treated with kissing stenting. DES type was not different between the two groups. Simultaneous kissing group received DES with higher deploy pressure. At 6 to 9 months, angiographic follow up results showed larger follow up minimal luminal diameter (MLD) and lower late loss (LL) in the sequential kissing group (Table). There were no significant differences in major clinical outcomes between the groups up to 12 months. Conclusion: Sequential kissing stenting appears to be the better technical strategy in reducing restenosis and late loss in LM bifurcation intervention but failed to show the better clinical outcomes up to 12 months. Further updated data with larger study population will be needed to get the final conclusion.