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ȣ - 520048 72 |
Composition of prolapsed plaque and intracoronary thrombus: An integrated backscatter intravascular ultrasound analysis
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중앙대학교병원 순환기내과 심장센터 |
김상욱, 이왕수, 조영미, 김기환, 이광제, 서기우, 김은영, 김태호, 김치정, 류왕성 |
Histopathologically-validated Virtual Histology (VH) intravascular ultrasound (IVUS) is able to assess plaque composition, but not thrombus. Conversely, radiofrequency based-integrated backscatter (IB) IVUS can assess thrombus as well as plaque composition. Methods. We used pre- and post-stent impantation IB-IVUS to assess 23 intra-stent plaque prolapse and 33 intracoronary thrombus. Results. Pt age was 61±9.9 yrs; 85% were males. The lesion length was 25.4±12.45 mm and prolapsed plaque area measured 0.73±0.61mm2. The main component of prolapsed plaque was fibrosis and small lipid pool. Similarly, fibrosis was the dominant component of intracoronary thrombus. However calcification was higher in prolapsed plaque(p=0.053). The % of IB values (range -29% ~ -35%) was higher in intracoronary thrombus(p=0.0004) vs prolapsed plaque showed higher % of IB values (range -49% ~ -130%)(p=0.001). The frequency of mean IB values (> -40dB) was lower in thrombus [25/33(76%) of intracoronary thrombus vs 22/23(96%) of prolapsed plaque, p=0.046]. Overall, the mean IB values(dB) was higher in plaque prolapse (p=0.001)(Table). Conclusion. The fibrosis was a dominant component in both of prolapsed plaque and intracoronary thrombus, however, IB values may comparable to differentiate the intracoronary thrombus
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Plaque prolapse |
Thrombus |
p-value |
Dense Fibrosis, % |
12.35±8.61 |
12.90±8.67 |
0.816 |
Fibrosis, % |
66.31±9.36 |
71.69±7.07 |
0.017 |
Lipid pool, % |
16.28±9.69 |
13.73±9.03 |
0.318 |
Calcification, % |
5.05±7.76 |
1.66±2.21 |
0.053 |
IB values, mean(dB) |
-44.52±2.80 |
-41.72±2.85 |
0.001 |
IB values, -11.0 ~ -29.0(%) |
0.87±2.94 |
1.66±2.37 |
0.27 |
IB values, -29.0 ~ -35.0(%) |
6.27±6.16 |
14.08±8.59 |
0.0004 |
IB values, -35.0 ~ -49.0(%) |
69.45±6.84 |
70.47±8.31 |
0.631 |
IB values, -49.0 ~ -130(%) |
23.41±10.88 |
13.77±10.18 |
0.001 |
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