Background: Multidetector computed tomography (MDCT) has high diagnostic value for detecting or excluding coronary artery stenosis in symptomatic patients. But, the role of MDCT for routine health examination in asymptomatic patients is not established. We hypothesized that MDCT could be a valuable method to detect subclinical coronary artery stenosis. Methods: In a prospective, single-center, observational study, 1649 volunteers were underwent MDCT for routine health examination from Nov 2005 to Apr 2008. 120 patients were excluded due to their past history of coronary artery disease, typical chest pain, or evidence of myocardial ischemia on laboratory data, ECG, or Echo. 1529 patients (56.4 짹 8.3 years, 1353 males) were enrolled in our study. Results: 969 (63.4 %) patients were presented with normal findings and 560 (36.6 %) patients were presented with abnormal findings in MDCT. The patients with abnormal findings was classified into two groups, the one was presence of coronary calcium, but luminal diameter stenosis of coronary artery < 50 % (n = 508, 33.2 %). These patients were treated by medication. And, the other was luminal diameter stenosis of coronary artery ��� 50 %, presence or absence of coronary calcium (n = 52, 3.4 %). These patients were underwent conventional coronary angiogram and intravascular ultrasound. 29 patients (1.9 %) were presented with insignificant stenosis or myocardial bridge. These patients were treated by medication. 23 patients (1.5 %) were presented with significant stenosis. 17 patients were one vessel, 4 patients two, 2 patients three. The lesion artery was left anterior descending artery in 18 patients, left circumflex artery 6, and right coronary artery 6, and left main artery 1. They underwent percutaneous coronary intervention according to the basis of the coronary anatomy. The major adverse cardiac events were occurred in 2 patients during 387.4 짹 252.8 days (mean clinical follow-up period). Conclusions: The incidence of subclinical significant coronary stenosis examined by MDCT in general population was 1.5 % in our study. 64-Slice MDCT can be an useful tool for noninvasive evaluation of coronary arteries in asymptomatic patients.