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Clustering of cardiovascular risk factors in prehypertension and hypertension in a Korean general population : Atherosclerosis RIsk of Rural Area iN korea General population (ARIRANG) study
연세대학교 원주의과대학 심장내과¹ 예방의학과² 충남대학교 예방의학과³조선대학교 예방의학과 ⁴
안민수¹, 이경훈¹ 신명상¹ 김장영¹ 유병수¹ 이승환¹ 윤정한¹ 최경훈¹ 고상백² 박종구² 손동국² 이태영³ 류소연⁴
Background and objective: Risk factors such as dyslipidemia, hyperglycemia, and obesity are more frequent in hypertensive than in normotensive subjects. Recognition that cardiovascular risk factors often cluster together has focused attention on the concept of total cardiovascular risk. Information regard to the associations between hypertension and cardiovascular risk factors in Korean general population is limited. We investigated the associations between hypertension and cardiovascular risk factors in Korean general population. Methods: The study subjects were enrolled 6,191 Korean adult subjects (2,659 men, 3,532 women) from the five rural areas of the KGRC, an ongoing epidemiologic study conducted on a representative senior population. We excluded subjects with treatment of diabetes mellitus, hypertension, and hyperlipidemia. and We divided into three (normotension, prehypertension and hypertension) groups by JNC7. Cardiovascular risk factors were defined as smoking, abdominal obesity (waist circumference >90cm in male, >85cm in female), low HDL-cholesterol (<40mg/dL), high LDL-cholesterol (>160mg/dL), diabetes (fasting blood glucose ≥126mg/dL) and high CRP ( > 1 mg/dL). The metabolic syndrome (Mets) was defined according to the modified ATP III criteria. Results: The clustering of risk factors among study groups are shown below table. Conclusion: Increasing blood pressure frequently clusters with other cardiovascular risk factors, such as obesity, and metabolic syndrome.

?

Normotension

( n =1238 )

Prehypertension

( n =2324 )

Hypertension

( n =2329 )

p

Age (year)

54.5±8.3

55.4±8.2

56.2±8.1

<0.001

MetS by ATP III (%)

8.2

22.8

39.7

<0.001

N. of Additional risk (%)

?

?

?

0.001

0

28.1

25.9

24.5

?

1

35.4

36.4

32.9

?

2

25.7

25.2

28.3

?

3

8.8

10.5

11.2

?

4

1.9

2.0

3.1

?



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