Background and Aims: Chronic renal failure (CRF) is an important independent risk factor for cardiovascular disease (CVD). We investigated the combined effects of renal dysfunction and CRP on outcomes in patients who underwent percutaneous coronary intervention (PCI) using drug eluting stent (DES). Methods: In this study, total 1861 patients (mean age 64짹10ys) who underwent PCI with DES between Feb. 2003 and Jun. 2006, were divided into 3 groups according to renal function at admission: (1) glomerular filtration rate (GRF) less than 30 mL/min/1.73 m2 (Gr 1, N=110); (2) GFR of 30 to 59 (Gr 2, N=412); and (3) GFR greater than 60 (Gr 3, N=1339). Results: Patients in Gr 1 showed higher incidences of hypertension and diabetes. Regarding angiographic characteristics, patients in Gr 1 showed the highest incidence of type C lesion (Gr 1; 74.5%, Gr 2; 64.1%, Gr 3; 62.7%, P = 0.038) and left main disease (Gr 1; 10.0%, Gr 2; 6.1%, Gr 3; 4.6%, P=0.015) among three groups. Major adverse cardiac events (MACE) during mean follow up duration of 21.8짹12.1 months, were significantly higher in Gr 1 (39.1%; 43 pts) than in the other two groups (Gr 2=22.3%; 92 pts, Gr 3=18.8%; 246 pts) (P < 0.0001). In addition, high hsCRP increased the risk of MACE (hsCRP greater than 3 mg/L; 36.2%, 1-3 mg/L; 23.2%, less than 1 mg/L; 18.3%, P < 0.0001). We found a significant difference between normal GFR/CRP group and extremely abnormal GFR/CRP group (18.2% and 59.3%, respectively, P < 0.0001) of risk of MACE. Conclusion: The levels of renal function and hsCRP are predictor of major adverse cardiac events in a dose dependent fashion following PCI with DES.