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ȣ - 510723 172 |
Coronary Flow Reserve is Related to 10-Year Risk by Framingham Risk Scores in Subjects with Chest Pain and Normal Coronary Angiogram |
가톨릭 대학교 의과대학 순환기 내과 |
이동현, 윤호중, 박철수, 임상현, 최윤석, 박정환, 이종민, 오수성, 오용석, 정욱성, 승기배, 김재형, 최규보, 홍순조 |
Background and Aim : The syndrome of angina or angina-like chest pain with a normal coronary angiogram, often referred to as syndrome X is an important clinical entity and has usually an excellent prognosis. Although the exact mechanism of this syndrome has not been clearly defined, the decreased coronary flow reserve(CFR) has been suggested as a most important etiology. The aim of this study was to elucidate the relation between CFR and Framingham Risk Score (FRS) in subjects with chest pain and normal coronary angiogram.
Methods : 354 subjects (M:F= 186:168, mean age: 55±11 years) with chest pain and a normal coronary arteriogram were enrolled. CFR using of transthoracic Doppler echocardiography (TTE) and adenosine or dipyridamole was measured within two weeks after coronary angiogram. We compared CFR with FRS .
Results : 1.FRS was 12.6±4.4 in subjects with CFR < 2.0. 2. FRS was 10.9±5.5 in subjects with 2.0≤CFR<3.0. 3. FRS was 9.75±5.9 in subjects with CFR≥3.0. 4.There was a significant difference in FRS between subjects with CFR < 2.0 and CFR≥3.0.(p<0.001) 5. CFR had an inverted correlation with FRC (R=-.222, p<.001)(Fig).
Conclusions : Our results suggest CFR is closely related to FRS and the impaired CFR can predict the high 10-year risk of coronary artery disease even in subjects with chest pain and normal coronary angiogram.
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