ǥ : Clinical award session
|
ȣ - 510616 16 |
A new Doppler index for assessment of left ventricular diastolic function: Ratio of early diastolic transmitral inflow velocity to late diastolic mitral annular tissue velocity in patients with coronary artery disease |
을지대학교 의과대학 순환기내과 |
이경진, 최유정, 이상, 김정희, 유연표, 정경태, 박순창 |
Background: Late diastole is related with left ventricular stiffness. Our hypothesis was that the combination of both early and late diastolic parameters may predict LV end-diastolic pressure (LVEDP) more accurately than the previous index, E/e' ratio which uses only early diastolic parameters.
Methods: LVEDP and coronary angiogram (CAG) were obtained within 2-h after standard echocardiography with tissue Doppler imaging. Medial and lateral mitral annular tissue velocities were obtained and mean value was used for analysis. Patients with normal CAG were excluded.
Results: A total of 50 patients (30 men; mean ages, 63.2 ± 9.8 years) were enrolled. LV ejection fraction was 68 ± 11 %. E/e’ ratio showed positive correlation with LVEDP (r = 0.406, p = 0.003).The ratio of E velocity to late diastolic mitral annular tissue velocity (E/a') showed stronger positive correlation with LVEDP (r = 0.502, p < 0.001) compared to E/e’ ratio (Figure 1). The ratio of A velocity to a’ velocity (A/a’) did not show significant correlation with LVEDP (r = 0.233, p = 0.104). In ROC curve analysis, an E/a’ ratio > 8 was the optimal cut-off value for predicting LVEDP > 15mmHg with a sensitivity of 77% and specificity of 76% (Figure 2).
Conclusion: E/a' ratio which uses both early and late diastolic Doppler parameters showed better correlation with LVEDP compared to E/e’ ratio in patients with coronary artery disease. E/a' ratio may be used as an alternative index for the assessment of diastolic function.
|
|
Warning: getimagesize(/home/virtual/circulationadmin/htdocs/econgress/conference/abstract/img_files/Figure_LVEDP.jpg) [function.getimagesize]: failed to open stream: No such file or directory in /home/virtual/circulationadmin/new/econgress/conference/manage/schedule/view_abstract.php on line 164
|
|