학술대회 발표 연제 초록

Backgrounds: In obstructive sleep apnea (OSA) patients, apnea-hypopnea event can induce impaired arterial endothelial dysfunction, reduce nitric oxide derivative and increase sympathetic nerve activity. The increased sympathetic nerve activity in OSA patient may increases arterial stiffness because the elasticity of muscular artery is more strongly regulated by sympathetic nerve system. However, there is no study about the association between arterial stiffness and OSA. Methods: A total of seventy six patients (twenty of OSA patients) were enrolled. Brachial-ankle pulse wave velocity (baPWV), heart rate, systolic and diastolic blood pressure were measured. OSA was diagnosed by overnight �봯olysomnography. We compared the CVD risk factors and arterial stiffness in patients �쐗ith OSA�� to those of �쐗ithout OSA�� Results: OSA group were more likely male, smoker, and increased BMI and baPWV. There were no significant differences in hemodynamic parameters such as SBP, DBP, and HR. In multivariate regression analysis, OSA was only significant independent risk factor for increased baPWV (odd ratio = 6.34, p=0.017) Conclusions: We found that baPWV increased in OSA patients. This finding suggests that increased arterial stiffness may responsible for development of CVD in OSA patients.