학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


мȸ ǥ ʷ


Warning: getimagesize(/home/virtual/circulationadmin/htdocs/econgress/conference/abstract/img_files/Figure_.png) [function.getimagesize]: failed to open stream: No such file or directory in /home/virtual/circulationadmin/new/econgress/conference/manage/schedule/view_abstract.php on line 164
ǥ : ȣ - 500665   144 
Left ventricular hypertrophy is associated with decreased contractile reserve during exercise in patients with hypertension
연세대학교 의과대학교
서혜선, 박성하, 심지영, 이지현, 최의영, 최동훈, 하종원, 임세중, 정남식
Background: LV hypertrophy (LVH) is associated with reduction of subendocardial coronary flow reserve. Because the subendocardial layer consists mainly of longitudinal fibers, the exaggerated decrease in coronary flow during exercise may result in decrease of longitudinal contractile reserve. Therefore, we hypothesized that LVH is associated with diminished longitudinal contractile reserve in hypertensive patients. Methods: A total of 182 patients with hypertension who complained of exertional dyspnea were enrolled.(mean age: 56.6±10.3) Patients were classified as follows: patients with normal geometry (Group 1) vs. concentric remodeling (Group 2) vs. LVH (Group 3). Exercise stress echocardiography was performed using a symptom limited, multistage supine bicycle test. Variable Doppler parameters were obtained at baseline, at each stage of exercise, and during recovery. Results: There was no significant difference in baseline characteristics between the three groups. However E/E’, an index of LV filling pressure, was significantly higher in group 3 at rest and during exercise. Although the baseline value of annular systolic tissue velocity(S’) was not significantly different between the three groups at baseline, S’ was significantly lower in group 3 during exercise. The changes of S’ from baseline, the longitudinal contractile reserve, was significantly lower in the LVH group. Multiple regression analysis also showed independent association of LV mass index with peak longitudinal contractile reserve.
̹ 󼼺


[ư]