학술대회 안내 사전등록 안내 초록등록 안내 초록등록/관리 숙박및교통 안내


мȸ ǥ ʷ

ǥ : ȣ - 500644   148 
Aortic pulse wave velocity (PWV) as a predictor of masked hypertension in treated patients
한림대학교 한강성심병원
김 민규, 김성환, 박우정, 조구영, 김현숙, 정재헌, 홍경순, 오동진, 임종윤
Background Masked hypertension (MH), a condition in which classified as normotensive by office measurement are hypertensive with ABPM, was one of those interesting patterns. Such patients have increased rates of cardiovascular morbidity, almost as high as seen in those with both clinic and ambulatory hypertension. But there is little study for clinical features of masked hypertension in the treated hypertensives. We investigated the clinical features and any predictors of MH in treated hypertensive patients. Method From Jan. to Dec. 2005, we evaluated ABPM, echocardiogram, PWV, and office BP simultaneously in treated hypertensives. Office and awake SBP > 140 mmHg were classified as hypertensive. We compared well-controlled hypertensives (group I) with MH (group II). Results Total of 505 patients had completed ABPM appropriately. 32.2% (162), 8.3% (42) comprised group I and II respectively. Baseline characteristics showed in table 1. By logistic regression analysis including age, office BP, BMI, LV mass and PWV, BP and PWV were always statistically significant for masked hypertension. By ABP data, all kinds of BPs were higher in group II significantly (table 2). Conclusion We thought that in the well-controlled hypertensives classified by office measurement, old-aged patients showing a high aortic PWV might have a MH. So recommended the ABPM in those patients and added additional antihypertensive medications.

Table 1. Baseline characteristics

 

Group I (n=162)

Group II (n=42)

P value

Clinic SBP (mmHg)

126.2±9.9

132.2±7.4

.000

LV mass index (g/m2)

117.1±3.4

134.5±7.4

.025

hcPWV (cm/s)

887.7±251.8

1031.3±257.5

.011

hfPWV (cm/s)

958.7±155.0

1175.1±340.6

.000

Table 2. ABPM data

(mmHg)

Group I (n=42)

Group II (n=162)

P value

24-hour BP

122.7±9.1/80.7±7.8

143.5±8.6/93.4±8.0

.000

night BP

114.2±10.9/73.8±8.6

132.2±15.0/84.0±12.1

.000

preawake BP

115.5±11.7/62.8±9.1

133.6±15.4/86.0±10.3

.000

morning BP

127.7±12.5/85.8±15.6

148.1±13.8/97.9±13.7

.000



[ư]