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ȣ - 500197 1 |
Relationship between testosterone level and electrocardiographic parameters in subjects with normal testosterone level |
경북대학교 병원 순환기 내과 |
박용휘, 이동엽, 장귀련, 이현상, 양동헌, 박헌식, 조용근, 채성철, 전재은, 박의현 |
Background: Direct comparison between testosterone levels and ST-segment elevations in the right precordial leads has never been elucidated in subjects with normal testosterone level.
Methods: This study included 75 adults with no evidence of cardiac disease and normal testosterone levels. No subjects had typical symptom or family history of Brugada syndrome. We evaluated the association between testosterone levels and ECG parameters in these subjects. Measurements of ECG variables were carried out electronically with Photoshop 7.0.1 from scanned ECGs. We used Bazett’s formula to calculate the corrected QT interval (QTc).
Results: All subjects were in sinus rhythm without typical ST-segment changes of Brugada syndrome. Male subjects had more elevated ST-segments in V1 and V2 than those of female subjects. Female subjects showed more prolonged QTc interval than that of male subjects (Table). There were significant correlation between testosterone levels and ST-segment elevations in the right precordial leads (r2=0.137, p=0.001) and inverse correlation between testosterone level and QTc interval (r2=0.078, p=0.015).
Conclusion: Significant correlations between testosterone levels and ECG parameters such as ST-segment elevations in the right precordial leads and QTc interval in adult subjects with normal testosterone level were observed.
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Table.
Comparisons of Testosterone levels and ECG variables between genders
|
Total |
Male
(n=43) |
Female
(n=32) |
P
value* |
Age
(years) |
40±13 |
40±14 |
38±11 |
0.48 |
Testosterone (ng/ml) |
2.8±2.4 |
4.7±1.2 |
0.3±0.2 |
<0.001 |
Heart rate (beat/minute) |
68±14 |
67±13 |
68±14 |
0.37 |
QT
interval
(ms) |
389±41 |
387±41 |
391±40 |
0.60 |
Corrected
QT interval
(ms) |
410±24 |
403±25 |
418±21 |
0.006 |
J-point
elevation in V1 (mm) |
0.22±0.40 |
0.35±0.41 |
0.05±0.31 |
0.001 |
ST20 in V1 (mm) |
0.53±0.42 |
0.65±0.45 |
0.36±0.33 |
0.002 |
J-point
elevation in V2 (mm) |
0.61±0.73 |
0.91±0.77 |
0.20±0.41 |
<0.001 |
ST20 in V2 (mm) |
1.12±0.87 |
1.57±0.82 |
0.52±0.49 |
<0.001 | *=
male vs. female, ST20
= amplitude of the ST-segment elevation 20ms after the end of the QRS
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