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ȣ - 500130 35 |
Magentic Dispersion is a Common Finding in Sudden Cardiac Death Survivals ? |
연세대학교 의과대학 심장내과, 한국표준과학연구원¹ |
정보영, 김기웅¹ , 이용호¹ , 권혁찬¹ , 김태은¹ , 고영국, 이문형, 정남식, 김성순 |
Background: The causes of sudden cardiac death (SCD) are variable. However, the ventricular fibrillation (VF) caused by electrical unstability is the main final cause of SCD. Magnetocardiography (MCD) is a new noninvasive tool to evaluate the depolarizaiton and repolarization abnormality of heart. The objective of this study was to evaluate the MCG findings of SCD survivals with a 64-channel MCG and to confirm in MCG simulation model.
Methods: The MCG findings of 9 SCD survivals (all male, 37.0 ± 7.7 years) and 8 control (6 male, 40.4 ± 17.1 years) were analyzed. All SCD survivals had experienced VF, and the underlying disease was as follows ; 4: Brugada syndrome, 2: coronary artery disease, 2 idiopathic, 1: hypertrophic cardiomyopathy. Magnetic field (MF) and conduction density vector (CDV) map were evaluated every 10 msec from the onset of QRS and the end of T-wave (Te). Especially during repolarization, MF map was classified into dipole and non-dipole, In CDV map during repolarization, the number of vortexes was calculated.
Results: MCG was recorded 6.2 ± 8.8 days after VF. SCD survival had more non-dipole pattern in MF map and more vortexes in CDV map than normal from Te-20 ms and Te-60 ms. This dispersion of repolarization was changed with variable ECG changes in Brugada syndrome patients. In MCG simulation model, Brugada syndrome and myocardial ischemia showed magnetic dispersion of repolarization.
Conclusion: In all SCD survival, the dispersion of repolarization was observed. This magnetic dispersion pattern can be the common finding in SCD survival and MCG might be used as a new noninvasive tool to evaluate SCD survival.
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Comparison
of MCG repolarization parameters between control and SCD
survival
Time |
Non-dipole
pattern in MF map (n) |
Number
of vortexes in CDV map (n) |
Normal |
SCD |
P-value |
Normal |
SCD |
P-value |
Te |
8/9 |
9/9 |
- |
2.0
±
0.0 |
2.0
±
0.0 |
- |
Te-20ms |
2/8 |
9/9 |
0.002 |
0.5
±
0.9 |
2.0
±
0.0 |
0.001 |
Te-40ms |
0/8 |
9/9 |
0.001 |
0.0
±
0.0 |
2.0
±
0.0 |
0.001 |
Te-60ms |
0/6 |
6/3 |
0.03 |
0.0
±
0.0 |
1.3
±
1.0 |
0.007 |
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