ǥ :
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ȣ - 500066 52 |
The Changes of Endothelial Function in Variant and Stable Angina
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전남대학교병원 심장센터, 광주원광대학병원 |
조숙희, 정명호, 황선호, 윤남식, 홍서나, 이우석, 김계훈, 홍영준, 박형욱, 김주한, 안영근, 조정관, 박종춘, 강정채, 박옥규 |
Background: The aim of this study was to investigate differences of endothelial function assessed by flow-mediated dilation (FMD), which is an dependent predictor for endothelial function and nitrate-mediated dilation (NMD), which is an independent factor for endothelial function of brachial artery between vasospastic angina (VA) and stable angina (SA).
Methods: One hundred twenty three patients were divided into 3 groups according to coronary angiographic findings: no significant coronary artery disease (CAD) and no ergnovine-induced coronary artery spasm (control group: n=40, 52.6±10.3 years, 22 males), ergonovine-induced coronary artery spasm without significant coronary stenosis (VA group: n=43, 53.7±12.0 years, 18 males) and stable angina due to significant CAD (SA group: n=40, 54.8±10.6 years, 28 males). FMD and NMD were measured in the same day morning before diagnostic coronary angiogram.
Results: The FMD was 9.3±4.2 % in control group, 9.2±4.4 % in VA group, and 7.2±3.4 % in SA group. The FMD was significantly decreased in the SA group compared with control group (p=0.045). The NMD was 21.2±6.4 % in control group, 23.6±9.5 % in VA group, and 17.8±9.5 % in SA group. The NMD was significantly increased in the VA group compared with control group (p=0.011).
Conclusion : The flow-mediated endothelial function was impaired in stable angina, but maintained in variant angina with hyper-responsiveness to nitrate.
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