Speckle tracking echocardiograph(STE) can provide a powerful means for assessing left ventricular torsion(LVtor). This study sought to assess 1)the feasibility of STE in measurement of LVtor, and 2)the relationship of LVtor with age and conventional echocardiographic parameters. We consecutively recruited 160 healthy volunteers. After obtaining conventional echocardiographic parameters, apical and basal short axis rotations were assessed with STE. LVtor was defined as the net-difference between rotation angles in the two short-axis planes normalized for left ventricular(LV) longitudinal length. Reliable LVtor measurement was possible only in 56 subjects(35%). This low feasibility was largely due to the failure to obtain reliable basal rotation values. In 56 subjects finally enrolled, a significant correlation was found between LV ejection fraction and LVtor and this correlation is attributed to apical but not to basal rotation(Figure). There was no significant change in LVtor with aging. But, initial counterclockwise motion and its interval in the basal rotation gradually decreased with aging, and correlated with mitral E velocity and its deceleration time(Figure). In contrast, such correlations were not found for initial clockwise motion and its interval in the apical rotation. In conclusion, STE has limited feasibility in measurement of LVtor. There was no significant age-related change in LVtor. Basal rotation was affected by the age-related changes in the LV early diastolic filling, while apical rotation is related to LV systolic performance.