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ȣ - 490340 5 |
A Prospective Multicenter Randomized Comparison of Paclitaxel versus Sirolimus-Eluting Stents For Long Coronary Lesion: 6-Month Angiographic Follow-Up Study |
soonchunhyang university bucheon hospital,¹ Chonbuk National University Hospital,² Chungnam National University Hospital³ |
Seung-Whan Lee¹, Hyun-Sook Kim,² Jae-Hwan Lee,³ Jae-Hyeong Park, Jae-ki Ko,² Si-Wan Choi,³ In-Whan Seong,³ Nae-Hee Lee,¹ Youn-Haeng Jo¹ |
Background: Several drug-eluting stents (DES) have been demonstrated to significantly reduce the restensosis. It is not known, however, which of these DES, is more effective for long coronary lesion. Therefore, we performed a prospective randomized study comparing paclitaxel- (PES) and sirolimus-eluting stents (SES) for long coronary lesion (vessel size > 2.75mm. requiring long DES ≥ 30 mm).
Methods: Patients requiring long DES were randomly assigned to receive PES (Group I, n=100) or SES (Group II, n=101). The primary end point was in-segment late loss and the secondary end point was angiographic restenosis at 6 months and major adverse cardiac events (nonfatal myocardial infarction, death, target lesion revascularization) at 9 months.
Results: The baseline clinical and angiographic characteristics were similar between the 2 groups. The lesion length and mean stent length were also similar between the 2 groups (Table 1). Procedural success was 99% in group I and 100% in group II. One in-hospital death occurred in group I. In-hospital events including myocardial infarction, target lesion revascularization, or stent thrombosis did not occurred. Six-month angiographic and nine-month clinical outcomes will be obtained until meeting.
Conclusions: Treatment with PES or SES was safe and had a similarly short-term clinical outcome. The six-month angiographic and nine-month clinical outcomes will be presented at the meeting.
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Table 1.
Procedural characteristics
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Group
I |
Group
II |
P
value |
Reference
size (mm) |
2.97±0.40 |
2.88±0.36 |
1.89 |
Lesion
length (mm) |
35.3±11.7 |
35.4±11.3 |
0.98 |
Total
stent length (mm) |
39.3±12.7 |
42.6±14.3
|
0.15 |
Pre
MLD (mm) |
0.57±0.36 |
0.62±0.40 |
0.47 |
Post
MLD (mm) |
2.85±0.38 |
2.69±0.53 |
0.69 |
Acute
gain (mm) |
2.28±0.50 |
2.25±0.48 |
0.74 |
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