Background:Ideally, the primary goals of stent-graft implantation in type B dissection are the complete exclusion of the false lumen and relief of branch vessel ischemia. Current stent-graft implantation strategy is focused upon blocking the entry tear site of the descending aorta. However, continuous flow through the reentry tears may result in the development of aortic aneurysms and subsequent risk of rupture. We experienced 5 cases of endovascular treatment of aortic dissection with the intent to close all the entry and reentry tears with the goal of excluding all the false lumen and normalizing the true lumen of the aorta as much as possible among 42 cases. Methods :Patients diagnosed with type B dissection without major branch vessels being supplied by the false lumen were included. The indications for stent-graft insertion were progression of dissection, intractable pain, aortic diameter of 6cm or more, continuous false lumen leakage. The procedure was performed in multiple stages. Initial stent graft implantation was performed with the intent to cover all the entry tears as much as possible with multiple stent grafts. The residual entry tear sites at short term followup were treated by glue embolization or additional stent graft implantation. Results: Five of 42 patients' (12%) aortic lumen were normalized after procedures and their median followup duration was 41 months. Despite the implantation of multiple stent grafts which extended into the abdominal aorta, there were absence of periprocedural mortality or of paraplegia. The patients undergoing the normalization procedures showed absence of significant endoleaks, saccular aneurysm formation and false lumen enlargement during followup. Two of these patients received glue embolization at intercostal artery or internal iliac artery and another 2 patients had postimplantation syndrome with good result. Conclusions: Our results of the endovascular attempts to normalize the aorta in type B dissection appears safe and effective. However, clinical experience to determine the appropriate indications for this procedure is needed. Long term randomized trial to compare the outcome with conventional proximal DTA stent-graft implantation is required as well.