| ǥ :
|
ȣ - 490090 12 |
| Risk factors of In-stent Restenosis in Drug-eluting stents |
| Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea |
| Hyeon Gook Lee, Kook Jin Chun, Jun Hyuk Oh, Dong Won Lee, Byung Jae Ahn, Seong Ho Kim, Joon Sang Lee, Moo Young Kim, Woo Hyung Bae, Jun Kim, June Hong Kim, Taek Jong Hong, Yung Woo Shin |
Backgroud: Although Drug-eluting stents (DES) have significantly reduced in-stent restenosis(ISR) in coronary arteries compared with bare-metal stents, restenosis still exists. Therefore we investigated risk factors of ISR in patients with DES implantation. Method: From January 2004 to July 2005, 270 patients (351 lesions) who were treated with DES and underwent follow-up coronary angiogram were selected for this study. Results: Mean-follow up duration was 9 months. At 6 months follow-up angiogram, 4.3% of lesions had binary ISR (2.8% SES, 11.1% PES). Clinical and angiographic data are in the below table. Baseline angiographic characteristics of ISR group were longer lesion length, smaller minimal lumen diameter, more complex lesion(ACC/AHA B2,C), and the presence of thrombi than NO ISR group. Conclusions: We suggest long lesion length, small minimal lumen diameter, complex lesion by ACC/AHA Class, and the presence of thrombi as risk factors of ISR in Drug-eluting stents.
|
Plus Web Editor Control By Ensys co., Ltd
|
(n=patient/lesion) |
ISR (14/15) |
No ISR (256/336) |
P value |
|
Age(yrs) |
59±10 |
58±10 |
NS |
|
Men(%) |
57 |
78 |
NS |
|
Target artery(%) :
LM/ LAD/ LCX/ RCA |
0/41/33/26 |
2/53/22/21 |
NS |
|
SA/ UA/ AMI(%) |
26/33/41 |
32/34/33 |
NS |
|
Pre-PCI
RD(mm) |
3.02±0.22 |
3.13±0.30 |
NS |
|
Pre-PCI MLD(mm) |
0.27±0.18 |
0.64±0.16 |
<0.05 |
|
*Lesion class :
A/ B1/ B2/ C |
0/6/14/80 |
12/62/2/24 |
<0.05 |
|
Lesion length(mm) |
33.47±16.68 |
20.14±9.04 |
<0.05 |
|
Stent : lesion length ratio |
1.14±0.07 |
1.23±0.10 |
NS |
|
Presence of thrombi(%) |
40 |
12 |
<0.05 |
|
Ostial lesion (%) |
6 |
9 |
NS |
|
Bifurcation lesion (%) |
13 |
19 |
NS |
ISR : In stent restenosis, LM : Left main coronary artery, LAD : Left
anterior descending arter, LCX : Left circumflex artery, RCA : Right coronary
artery, SA/ UA/ AMI : stable angina/ unstable angina/ acute myocardial
infarction, PCI : percutaneous coronary intervention, RD : Reference diameter,
MLD: Minimal lumen diameter, *Lesion class (A/B1/B2/C): American College of
Cardiology/American Heart Association class
|
|
|
