Background: Several studies reported the safety and effectiveness of stenting of left main coronary artery (LMCA) stenosis with bare metal stent. However, in-stent restenosis (ISR) still remained as a major problem in this lesion. We investigated the safety and effectiveness of DES in LMCA. Method: Thirty-eight consecutive patients (59짹10 years old, men: 27) with symptomatic LMCA stenosis had stenting with 39 DES (20 Cypher and 19 Taxus). Immediate results, follow-up clinical and angiographic outcomes were evaluated. Results: Twenty–seven patients (70%) were diagnosed as acute coronary syndrome, while 12 patients (30%) were with stable angina. Twenty-two procedures (56%) were performed for the LMCA only, while 17 procedures (44%) were performed for the LMCA and proximal LAD or LCX. In quantitative coronary angiogrpahy, lesion length was 15.6짹10.0mm, reference diameter was 3.4짹0.7mm, minimal luminal diameter was 0.7짹0.6mm (before) and 3.2짹0.5mm (after). The procedures were technically successful in all cases. Clinical and 6 month-angiographic follow-up were done in 37 cases (95%) and 9 cases (24%) respectively. During the follow-up (5.5짹3.2 months), 3 patients (8%) died (2 cardiac, 1 non-cardiac). Follow-up angiography revealed minimal luminal diameter of 2.5짹0.6mm and late loss of 0.6짹0.4mm. Conclusion: Stenting of LMCA with DES showed favorable clinical and angiographic outcome. However, data of long-term follow-up in large number of patients are still limited.