Background and aim: Sirolimus eluting stent(Cypher) has been widely used in dilating long lesion of coronary artery. However, there are few clinical data about Cypher stenting in long coronary lesions in Korea and it is known that drug eluting stent could be more thrombogenic than conventional bare stent. Therefore, we evaluated the feasibility of Cypher stenting and safety for subacute thrombosis in long coronary lesions. Methods: 35 patients(M:F=28:7, mean age: 59짹10 years) treated with longer than 28mm Cypher stents were included in this study. As an antiplatelet therapy, Aspirin (ASA) 100mg + Cilostazol(CLZ) 200mg + Clopidogrel(CLOPD) 75mg in 11 patients, ASA 100mg + CLOPD 75 mg in 20 patients, and ASA 100mg + Ticlopidine(TPD) 500mg in 4 patients have been prescribed. Results: 1) 35 patients and 49 lesions were dilated with Cypher stents. 2) Multiple overlapping Cypher stents were implanted in 12 lesions(24%). 3) Procedural success was observed in 35 patinets(100%). 4) No inhospital MACE were reported. 5) Any clinical events including subacute thrombosis were not reported in ASA+CLZ+CLOPD, ASA+CLOPD, and ASA+TPD group during 30-day clinical follow-up. 6) The complete clinical and angiographic follow-up data will be available at the time of presentation. Conclusion: The experience using sirolimus eluting stent in diffuse long coronary lesion has demonstrated the safety and feasibility with a 100% procedural success rate and an uneventful inhospital and 30-day follow-up, even with double antiplatelet therapy.