Background and Objectives :The long-term impact of elevated troponin T (TnT) or creatine kinase-MB (CK-MB) release after percutaneous coronary intervention(PCI) is not well defined. The purpose of the study is to evaluate the long-term effect of elevated TnT or CK-MB on the late major adverse cardiac events [MACE; Q wave myocardial infarction (MI), revascularization, or cardiac death] for 5-year follow-up. Subjects and Methods : Study population were 263 consecutive patients (M : F = 179 : 84, mean 60.05짹9.04 years) who underwent PCI. Patients with acute ST elevated or non-ST elevated MI or newly developed Q MI after PCI were excluded. Cardiac enzyme levels were measured before and 8, 24 hours after PCI for CK-MB, and before and 16 hours after PCI for TnT. Results : 5-year follow-up was available in 87.8% of patients(231/263). Incidence rate of elevated TnT or CK-MB after PTCA was 25.0% of patients(68/263). TnT or CK-MB elevation was significantly associated with a late MACE by Kaplan-Meier survival curve (p=0.003). Irregular or ulcerative lesion(p=0.04) or total or subtotal lesion(p=0.035) were significantly associated with an increased risk of late MACE. Elevation of TnT after PCI was independently predictive factor of long-term MACE(p=0.01). During 5-year follow-up, event free rate of Group I and II were 70.3% and 49.2%, respectively. Conclusion: Irregular or ulcerative lesion or total or subtotal lesion can increase the risk of late MACE. In addition, elevation of CK-MB or TnT after PCI dose significantly influence on late MACE.