Objectives: It has been suggested that inflammatory processes play a important role in the pathogenesis of acute coronary syndrome (ACS). And cardiac troponins are used as specific markers for the diagnosis of ACS. Methods and Results: We analyzed 28 normocholesterolemic (LDL cholesterol < 130 mg/dL) with ACS (60.0짹11.4 years) according to their troponin I status, troponin I-positive (n=18) and troponin I-negative patients (n=10) (cutoff 0.05mg/dL). NSTEMI and STEMI are more prevalent in troponin I-positive patients (p=0.01). In coronary angiographic findings, the number of vessels involved, AHA type classification, target vessel TIMI flow were not significantly different between the groups. A variety of inflammatory parameters [erythrocyte sedimentation rate (ESR), fibrinogen, high sensitive (hs) C-reactive protein (hsCRP), interleukin (IL)-1棺, IL-6, tumor necrosis factor (TNF)-慣, monocyte chemotactic protein 1 (MCP)-1, p-selectin] and left ventricular ejection fraction (LVEF) were compared between the groups.Positive troponin I patients were associated with higher levels of ESR (5.1짹2.7, 21.9짹6.5 mm/hr, p=0.029) and interleukin (IL)-6 (3.4짹1.5, 8.4짹1.1 pg/mL, p=0.013) compared with negative troponin I patients. And Troponin I is correlate positively with ESR and CRP (r=0.54, 0.52, p=0.012, 0.005, respectively). Conclusion: Troponin I is associated with ESR, CRP, and IL-6 in normocholeste rolemic patients with acute coronary syndrome. And these combined parameters can be an useful markers in normocholesterolemic patients with ACS.