| 발표형식 : 구연
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접수번호 - 470264 201 |
| Accute Effect of Nonsurgical Septal Reduction Therapy on Regional Left Ventricular Asynchrony in Patients With Hypertrophic Obstructive Cardiomyopathy |
| 1)Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine, Pusan, Korea, 2)Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas |
| Tae-Ho Park, MD1), Moo Hyun Kim, MD1), Young Dae Kim, MD1), Jong Seong Kim, MD1), William A Zoghbi, MD2), Sherif F. Nagueh, MD2) |
Background: Patients with hypertrophic obstructive cardiomyopathy have left ventricular (LV) diastolic dysfunction due, in part to temporal heterogeneity in regional function. The acute effect of the relief of LV outflow tract obstruction is unknown. Therefore, we investigated the effect of nonsugical septal reduction therapy (NSRT) on regional function. Methods and Results: Twenty-two patients (aged 56 짹 17 years) underwent echocardiographic examination, including assessed in 12 segments form which myocardial strain was obtained. Asynchrony was calculated as the coefficient of variation of the time interval from the QRS complex to the onset of expansion and to early diastolic strain. After NSRT, a significant reduction in LV outflow tract obstruction (from 57 짹 5 to 12 짹 3 mmHg) occurred with shortening of the time constant of LV relaxation (71 짹 4 to 61 짹 3 ms; both P<0.05). The coefficient of variation of the time interval to onset of regional expansion decreased significantly and related well to the changes in the time constant of LV relaxation (r=0.81, P<0.01). Conclusion: NSRT has a favorable effect on LV regional asynchrony, which accounts for the acute changes in LV relaxation.
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