νšŒμ›λ‘œκ·ΈμΈ

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급성심근경색 ν™˜μžμ—μ„œμ˜ λ²”λ°œμ„± 관상동λ§₯ μ—Όμ¦λ°˜μ‘
κ³ λ €λŒ€ν•™κ΅ μ˜λ£Œμ› μˆœν™˜κΈ°λ‚΄κ³Ό
신성희, μ˜€λ™μ£Ό, μ„œμˆœμš©, μž„ν™μ˜, λ°•μ„±λ―Έ, 김응주, μ΄μŠΉμ§„, μ•ˆμ •μ²œ, λ°•μ°½κ·œ, μ„œν™μ„, λ…Έμ˜λ¬΄

동λ§₯κ²½ν™”λ°˜μ˜ μ•ˆμ •λ„κ°€ ν—ˆν˜ˆμ„±μ‹¬κ·Όμ§ˆν™˜μ˜ κ²½κ³Όλ₯Ό κ²°μ •ν•˜λŠ”λ° μ—Όμ¦λ°˜μ‘μ€ 죽상동λ§₯κ²½ν™”μ˜ μ‹œμž‘κ³Ό νŒŒμ—΄μ— λ”°λ₯΄λŠ” 합병증 등에 영ν–₯을 λ―ΈμΉœλ‹€. μ „μ‹  μ—Όμ¦λ°˜μ‘μ€ 급성관동λ§₯μ¦ν›„κ΅°μ—μ„œ μ¦κ°€λ˜λŠ”λ°, 기원에 λŒ€ν•΄μ„œλŠ” ν™•λ¦½λ˜μ–΄ μžˆμ§€ μ•Šλ‹€. λ³Έ μ—°κ΅¬λŠ” 급성심근경색 (AMI) ν™˜μžλ₯Ό λŒ€μƒμœΌλ‘œ 심μž₯ν˜ˆκ΄€λ‚΄μ˜ μ—Όμ¦λ°˜μ‘ λΆ€μœ„μ™€ λ³‘λ³€ν˜ˆκ΄€κ³Όμ˜ 관련성을 λΉ„κ΅ν•˜μ—¬ μ—Όμ¦λ°˜μ‘μ˜ 기원에 λŒ€ν•΄μ„œ μ•Œμ•„λ³΄κ³ μž ν•˜μ˜€λ‹€. 방법:μš°κ΄€λ™λ§₯ (RCA, n=11) λ˜λŠ” μ’Œμ „ν•˜ν–‰μ§€λ™λ§₯ (LAD, n=13)이 병변인 AMI ν™˜μžλ₯Ό λŒ€μƒμœΌλ‘œ λŒ€λ™λ§₯κΈ°μ‹œλΆ€ (A), λ§μ΄ˆμ •λ§₯ (V), great cardiac vein (GCV)μ—μ„œ λ™μ‹œμ— ν˜ˆμ•‘μ„ μ±„μ·¨ν•˜μ—¬ ELISA λ°©λ²•μœΌλ‘œ Interleukin-6 (IL-6)λ₯Ό μΈ‘μ • λΉ„κ΅ν•˜μ˜€λ‹€. λŒ€μ‘°κ΅°μ€ LAD에 ν˜‘μ°©λ³‘λ³€μ΄ μžˆλŠ” μ•ˆμ •ν˜•ν˜‘μ‹¬μ¦ ν™˜μž (n=7)와 μ’Œκ΄€λ™λ§₯에 ν˜ˆκ΄€κ²½λ ¨μ΄ 증λͺ…λœ λ³€μ΄ν˜•ν˜‘μ‹¬μ¦ ν™˜μž (n=8)μ˜€λ‹€.

κ²°κ³ΌTable 1. Levels of IL-6 in 3 different sites. (pg/mL)

LAD

n=13

RCA

n=11

Stable angina. n=7

Var. angina. n=8

Aortic root

4.77Β±6.0

3.64Β±2.1

0.56Β±0.9

0.26Β±0.3

GCV*

11.32Β±11.3

6.05Β±4.9

0.47Β±0.8

0.37Β±0.8

Periph. vein

4.39Β±5.0

3.84Β±3.2

0.48Β±0.9

0.98Β±1.8

           *Selective drainage of blood from the LAD but not the RCA(p<0.05) 

 

           Table 2. Statistical significance (p value) in levels of IL-6.

LAD

RCA

Stable angina

Var. angina

Friedman test*

<0.01

<0.01

1

0.8

A - GCV†

0.01

<0.01

GCV - V†

0.02

<0.05

A - V†

0.78

0.93

           *Nonparametric test for comparisons within group.

           β€ Wilcoxon Signed Ranks test.

κ²°λ‘ : AMI ν™˜μžμ—μ„œ μ¦κ°€λœ μ—Όμ¦λ°˜μ‘μ˜ 기원은 λ³‘λ³€ν˜ˆκ΄€ λΆ€μœ„μ™€λŠ” 상관없이 심μž₯ν˜ˆκ΄€ λ‚΄μ—μ„œ λ²”λ°œμ„±μœΌλ‘œ κ΄€μ°°λœλ‹€. λ”°λΌμ„œ λΉ„λ³‘λ³€ν˜ˆκ΄€ λΆ€μœ„μ—μ„œλ„ 동λ§₯κ²½ν™”λ°˜μ΄λ‚˜ 심근에 손상이 λ°œμƒ ν–ˆμ„ κ°€λŠ₯성을 μ‹œμ‚¬ν•œλ‹€.



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