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ȣ - 470137 55 |
| Clinical characteristics, antioxidant status and cytokines in patients with microvascular angina |
| Department of Internal Medicine¹ , Department of Laboratory Medicine² , College of Medicine, Soonchunhyang University |
| Young Keun On¹, Rojin Park ² , Sang Ho Park¹ , Duck Won Bang¹ , Min Su Hyon¹ , Sung Koo Kim¹ , Young Joo Kwon¹ |
Background:
Microvascular angina or syndrome X is used to describe patients with exercise induced chest pain and a normal coronary angiogram. Several studies suggest that microvascular angina has favorable prognosis and occurs predominantly in postmenopousal women. Several causes and mechanisms have been investigated in the past years to explain both chest pain and ischemic angina-like ST segment depression. Arteriosclerosis of the small arteries is one of the main causes of microvascular angina. We investigated the clinical features, antioxidant status and cytokines in patients with microvascular angina.
Methods:
We studied 23 patients diagnosed of microvascular angina with positive treadmill test and normal coronary angiogram, and 21 control persons. We investigated the clinical characteristics in patients group and evaluated symptom during follow-up period of 14±2.5 month. Total antioxidant status were measured with RANDOX kit from RANDOX Lab using colorimetric method and the levels of cytokine were measured with P-seletin, MCP-1, IL-6, IL-10 kit from R&D Systems using ELISA method.
Results:
The two groups did not differ in the prevalence of diabetes mellitus, arterial hypertension and smoking history. The serum lipid profile, ESR, fibrinogen and homocytein levels were not different between two groups.
The levels of total antioxidant status and cytokines were listed in table.
The mean follow-up period was 14±2.5 months. Chest pain disappeared 21% after medication and chest pain had lessened in 37%. None of the patients died of cardiac event or suffered from a myocardial infarction or congestive heart failure.
Conclusions:
CRP levels were significantly higher in microvascular angina group. The serum MCP-1 levels were significantly higher in patients with microvascular angina than in controls. The prognosis of microvascular angina was favorable.
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|
CRP
(mg/dL) |
Homocytein
(umol/l) |
TAS
(mmol/l) |
P-selectin
(ng/ml) |
MCP-1
(pg/ml) |
IL-6
(pg/ml) |
IL-10
(pg/ml) |
|
Syndrome X |
2.8±1.74 |
10.5±0.77 |
1.4±0.36 |
4.1±2.76 |
85.6±43.08 |
2.8±7.86 |
19.9±34.15 |
|
Control |
0.3±0.11 |
9.9±0.72 |
1.7±0.54 |
4.1±1.71 |
61.5±19.43 |
0.9±2.64 |
19.4±39.69 |
|
p |
< 0.05 |
NS |
< 0.05 |
NS |
< 0.05 |
NS |
NS |
|
|
|
