Objectives: We tried to find the characteristics of risk factors in the korean patients with CAD with family history (FH) of CAD. Korea has lower prevalence of CAD compared with western countries and the positive FH of CAD can be found in about 5% of patients with CAD. So analyzing the risk factors of the CAD patients with FH of CAD in Korean may give us a clue to the genetic predispositions involved in Korean patients. Methods: We analyzed the major risk factors in 312 CAD patients with FH of CAD (FCAD) and in 4,572 CAD patients without FH of CAD (NFCAD). The CAD patients were diagnosed as CAD by coronary angiography at Samsung Medical Center from 1994 to 2003. Results: The mean age of FCAD was significantly younger than that of NFCAD. The means of body mass index (BMI), total cholesterol (TC) and LDL cholesterol were significantly higher in the FCAD. Significant differences in BMI, TC, and LDL were observed in the subgroup of male patients (Table 1), not in the subgroup of female. Conclusion: The risk profiles of FCAD showed significantly younger age, higher TC, LDL, and BMI compared with those of NFCAD, suggesting a genetic predisposition related to TC and LDL metabolism and obesity, especially in male patients. Table 1. Characteristics of risk factors in male CAD patients with or without FH of CAD.

	FCAD(male)	NFCAD(male)	P-value
Age (year)	55.7짹10.4	59.8짹10.0	<0.0001
Hypertension (%)	42.8	46.7	0.0285
Diabetes mellitus (%)	23.4	28.0	0.0015
BMI(kg/m2)	25.1짹3.2	24.6짹2.8	0.0128
TC (mg/dl)	196.6짹45.6	183.8짹38.9	0.0003
LDL (mg/dl)	130.9짹43.7	117.8짹33.4	0.0006
Smoking (%)	57.7	50.6	0.08