Background: Intravascular ultrasound (IVUS)-gudied stenting have contributed to new concept of stent implantation in clinical practice. Several studies have shown that IVUS-guided stenting improved an angiographic restenosis as well as clinical outcomes. The purpose of this study was to evaluate the influence of IVUS-guided stenting on 6-month angiographic restenosis rate and clinical outcomes compared with angiographically guided stenting. Methods: We analyzed 115 selected patients with 134 stents who underwent IVUS-guided or angiographically guided stent implantation. Standard clinical, angiographic, and IVUS parameters collected. The primary endpoint was a binary restenosis at 6-month follow-up angiography. The combined secondary endpoint was major adverse cardiac events (included death, non-fatal myocardial infarction; MACE) and target vessel revascularization (TVR) at 6-month follow-up. Results: See below. Conclusion: The IVUS-guided group showed a larger post-stent MLD and a larger stent size. There was no difference in the rate of MACE and TVR at 6-month follow-up between the two groups. Although statistical significance was not achieved, IVUS-guided stenting seems to decrease the restenosis rate at 6-month follow-up angiography.