Background and Objevtives: Probucol reduced stent restenosis by improving lumen dimension in a recent multicenter trial. However, it was administered for 2 weeks before and 4 weeks after stenting. Drug-release at site of vascular injury via polymer-coated stents helps achieve an effective local concentration. We assessed whether probucol stent coating is feasible and reduces in-stent restenosis. Subjects and Methods: Probucol loading and in vitro release were assessed using BiodivYsioTM stents in 50 mg/ml probucol solution. After being dip-coated with probucol (n=8) or control (n=8) solution, the stents were implanted in 8 pigs. Angiography and histopathologic analysis were done 28 days later. Results: Total probucol loading was 52짹16 關g/stent with no release up to 72 hours after loading. No pig died until sacrifice. On angiography, reference diameter and minimum lumen diameter were not different significantly between both groups, resulting in similar diameter stenoses (8.7짹3.68 vs. 13.3짹4.18 %, p=0.120). On histomorphometry, injury score, vessel area, lumen area, and neointimal area were not different significantly between both groups, resulting in similar area stenoses (23.1짹12.39 vs. 25.2짹8.22 %, p=0.671). Degrees of reendothelialization, inflammation, and smooth muscle cell proliferation were not different significantly. On immunohistochemistry, PCNA stain was not different significantly between both groups (15.94 짹 1.91 vs. 17.82 짹 1.45 %, p = 0.191). Conclusion: Probucol can be loaded onto a polymer-coated stent and does not release from the stents up to 72 hours after loading. About 52 關g probucol per stent does not reduce in-stent restenosis in porcine coronary arteries.