Background竊�Endovascular treatment (EVT) is considered as an effective treatment in patients (pts) with critical limb ischemia(CLI) who has active non-healing wound. There are very limited data regarding the association between trace elements and wounded lower extremities.Method: This study consisted of 128 consecutive CLI patients (pts) from June 2004 to November 2008. Among these pts, 46 (36%) pts presented with CLI with non-healing wound. We investigated whether there are differences in basal level of trace elements and vitamins between the wounded pts and pts without wound. Results: The baseline characteristics were similar between the two groups, except that more pts with wound suffered from ischemic symptom according to Rutherford Chronic Limb Ischemia Classification (p<0.001), diabetes (87.0% vs. 45.0%, p<0.001) and chronic renal insufficiency (CRI, 34.8% vs. 4.9%, p<0.001). Basal trace element and vitamin level showed lower ferrum and Vit E慣 levels (p<0.05) and Cu level was higher in the wounded pts (Table). Although there was no significant difference in angiographic successful rate between the two groups, pts with wound showed worse Limb Status Grade bilaterally after procedural (p<0.001) and higher rates of periprocedural complications such as dissection (48.7% vs 29.8%, p=0.004). However, the major clinical outcomes were similar between the two groups up to 6 months (Table). Conclusion: Besides presenting with more severe ischemic symptoms and procedural complications in CLI, pts with wound showed deficiency in some trace elements including Ferrum and Vit E 慣 and elevated Cu level, which might play a role in the development, progression or even healing of wound in pts with CLI.