Backgrounds: In drug eluting stent (DES) era, the predictors of target lesion revascularization (TLR) and target vessel revascularization (TVR) have been presented in many articles. But, there is no settled predictor of TLR/TVR. So we investigated which factors have an effect on TLR/TVR in addition, which factors are associated with percutaneous coronary intervention (PCI) of non target vessel lesion progression. Methods: We reviewed consecutive 2223 patients and 3012 lesions successfully performed PCI using DES and focused on revascularization such as target lesion, target vessel and non target lesion progression from 2003 to 2008 in Seoul St. Mary���s Hospital. Results: Patients underwent PCI by sirolimus-eluting stent, paclitaxel-eluting stent, zotarolimus-eluting stent, everolimus-eluting stent and their combination (60%, 27.2%, 4.6%, 6.9%, 1.3%, respectively). And among kinds of stent, there were no difference in clinical and angiographic characteristics. The incidence of TLR, TVR and non target vessel revascularization was 5.9%, 2.7% and 3.2%. According to cox hazard regression analysis, the predictors of TLR were stent diameter, bifurcation lesion and overlapping by other kinds of stents (table 1). In contrast, the predictor of TVR was current smoking (Hazard ratio (HR) 2.413, 95% confidence interval (CI) 1.019-5.716, P=0.045). And the predictors of non target vessel revascularization were male gender (HR 3.168, 95% CI 1.509-6.651, P=0.001) and total cholesterol level (HR 1.009, 95% CI 1.003-1.015, P=0.005). Conclusions: The risk of TLR is associated with procedural process such as stent diameter, bifurcation lesion and overlapping by other kind of stents, but the risk of TVR and non target vessel revascularization is associated with patients clinical characteristics such as smoking, gender and lipid profile.