Background:There is limited data about outcomes after treatment of drug-eluting stent(DES) restenosis. This study evaluated the intravascular risk factors for re-target lesion revascularization(TLR) after the treatment of DES restenosis.Methods:A total of 40lesions which underwent TLR for focal DES restenosis with cutting balloon angioplasty(CBA) were included in this study. The lesions were divided according to occurrence of re-TLR(re-TLR vs. no re-TLR). Intravascular ultrasound examination was performed before and after intervention with CBA. We measured the vessel, lumen, and stent area at the site of minimum lumen area and calculated plaque and neointima area. Clinical and angiographic variables were also gathered.Results:A total of 6cases of re-TLR have occurred(15%). Clinical variables were comparable between groups. Type of DES and lesion location were also comparable between groups. Restenosis length was not different between groups(7.09짹3.49mm vs. 9.16짹7.49mm,p=ns). Edge location of neointimal accumulation was more frequently seen with Re-TLR group(66.7% vs. 17.6%, p<0.05). Re-TLR group showed significantly greater vessel and plaque area compared with no re-TLR group. Neither the baseline neointima area nor final lumen area were not different between groups(Table).Conclusion: CBA for focal DES restenosis results in favorable clinical outcome. Lager plaque burden outside stent and edge location of restenosis is associated with re-TLR.