Background竊�Endovascular treatment (EVT) is considered as an effective treatment in patients (pts) with critical limb ischemia (CLI). There are very limited data whether the procedural and clinical outcomes can be different according to the presence of wound in pts with CLI following percutaneous translumianl angioplasty (PTA). Method: This study consisted of 128 consecutive lower extremity arterial disease pts enrolled from June 2004 to November 2008. Among these pts, 34 pts (26.5%) presented with CLI comprising active wound. All the enrolled pts with (n=34) and without (n=94) wounded lower extremities were treated with PTA. Procedural success, complications and clinical outcomes were compared between the two groups up to 6 months. Results: The baseline characteristics, were similar between the two groups, except that more pts with wounded lower extremities suffered worse ischemic symptom according to Rutherford Chronic Limb Ischemia Classification (p<0.05), diabetes (84.4% vs. 52.0%, p=0.001) and chronic renal insufficiency (CRI, 37.5% vs. 7.8%, p<0.001). Most of the chronic total occlusion (CTO) lesions were recanalized by subintimal angioplasty. Overall procedural success rate was 98% but there was no difference in angiographic successful rate between the two groups. Pts with wound showed worse Limb Status Grade bilaterally after procedural (p<0.01) and higher rates of periprocedural complications including dissection (48.7% vs. 29.8%, p=0.004). At 6 months, the cumulative clinical outcomes were similar between the two groups (Table). Conclusion: Although the CLI pts with wound presented with more severe symptoms and periprocedural complications, EVT offered good safety profiles and excellent clinical outcomes in CLI pts with wound similarly with those of the CLI pts without wound.