Background: Calcium scoring on MDCT and carotid intima-media thickness (IMT) have been widely used as indices of atherosclerosis. However, the clinical correlation between carotid IMT and the severity of coronary artery disease (CAD) is relatively poorly established. Calcium score on MDCT compares favorably with carotid IMT as a noninvasive index of prevalent CAD. The aim of this study was to determine the relation between coronary restenosis after DES implantation and carotid IMT, calcium score on MDCT. Methods: Among a total of 3720 patients who underwent carotid ultrasonography, 1053 patients (M:F=425:628, mean age=62짹11 years) with DES implantation who had undergone follow-up coronary angiography were divided into two groups. Group 1 (n=919, M:F=377:542, mean age 62짹11 years) was the no ISR group. Group 2 (n=134, M:F=48:86, mean age=65짹9 years) was the ISR group. ISR was defined as a more than 50% reduction in luminal stent diameter on follow-up coronary angiography after 6~9 months. Carotid IMT was measured using a 15 MHz high frequency transducer on the far walls of both carotid arteries. The calcium score on MDCT was also compared between the two groups. Results: On comparison between the two groups (group 1 vs group 2), 1. The right mean media thickness were larger in Group 2 (p=0.020). 2. Calcium scores were significantly higher on MDCT in the ISR group (446짹610 vs 938짹1061, p=0.013). (Table) On multivariate analysis after adjustment for HbA1C, the calcium score on MDCT was the strongest predictor of coronary artery restenosis (odds ratio 1.001, p=0.034, 95% CI: 1.000-1.002). Calcium score of cut-off value with 70% sensitivity and 65% specificity was 309. (Figure) Conclusion: The coronary calcium score is a better predictive marker for stent restenosis after DES implantation when compared to the carotid IMT.